A young CIA operative, Annie Walker, is mysteriously summoned to headquarters for duty as a field operative. While Annie believes she's been promoted for her exceptional linguistic skills, there may be something or someone from her past that her CIA bosses are really after. Auggie Anderson is a CIA military intelligence agent who was blinded while on assignment and is Annie's guide in this world of bureaucracy, excitement and intrigue.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

Two black FBI agents consigned to baby-sitting a pair of empty-headed socialites pose as the white party girls to flush out their would-be kidnappers.