In 1960s Alabama, an orphaned young boy staying with his grandmother at a hotel, stumbles across a conference of witches and gets transformed into a mouse by the Grand High Witch.

Tom the cat and Jerry the mouse get kicked out of their home and relocate to a fancy New York hotel, where a scrappy employee named Kayla will lose her job if she can't evict Jerry before a high-class wedding at the hotel. Her solution? Hiring Tom to get rid of the pesky mouse.