Having survived a brutal home invasion that left his fiancee dead, Scott, now emotionally unstable and reclusive is encouraged to join a support group in an attempt to get his life back on track. At the group he meets the enigmatic O, a woman who claims to have ties to Scott's attacker. Together the two set on a path of vengeance to track down the monster who did them wrong but as their journey progresses Scott begins to question O's true motives and intentions as she pulls him deeper into a world of murder and lies.

Paul and Jennifer Hemdale have just moved into their dream house. But their happy marriage is about to be put to the test as they slowly discover the secret behind the black room in the cellar. Something else is already living in their new home and it is growing stronger every day.

When an exotic dancer is murdered at a seedy strip club, her sister Constance, a TV newscaster, goes undercover to find the killer. While working at the club, she quickly realizes that everyone is a suspect and that other dancers are being targeted. She must work fast to find the killer to seek her revenge before she becomes the next target.

When a sorority girl falls in love with a zombie, it's only a matter of time before a zombie apocalypse is unleashed on campus. The sorority girl discovers that weed is the cure. Now, she must smoke out the whole school before it's too late.

Femme Fatales is an anthology TV series, inspired by the men's magazine of the same name, with each episode focusing on an antihero woman, intercut with softcore pornographic scenes and produced by Cinemax. Lilith, introduces each episode Rod Serling-style and occasionally appears within the narrative. Some characters make encore appearances in later episodes.