Ghost-Spider is on the run after being framed for her friend Kevin's murder, while Ms. Marvel, Squirrel Girl, Quake, and Patriot attempt to bring her in.

K.C. Cooper, a high school math whiz and karate black-belt, learns that her parents are spies when they recruit her to join them in the secret government agency, The Organization. While she now has the latest spy gadgets at her disposal, K.C. has a lot to learn about being a spy, including keeping her new gig a secret from her best friend Marisa. Together, K.C. and her parents, Craig and Kira, and her younger siblings, Ernie and Judy (a humanoid robot), try to balance everyday family life while on undercover missions, near and far, to save the world.

Jack Frost teams up with Santa, the Tooth Fairy and others to battle a malicious spirit determined to destroy the innocent beliefs of children.