The story of military hero Eric Carter’s return to the U.S. and the trouble that follows him back – compelling him to ask CTU for help in saving his life, and stopping what potentially could be one of the largest-scale terror attacks on American soil.

William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.