The film was released in two versions, titled Housefull 5A and Housefull 5B, each featuring a different climax and murderer.

Three couples who get separated from each other due to an evil ploy, reincarnate after 600 years and meet each other as history repeats itself again and their respective partners get mixed up this time.

A goon tries to win his wife back by making a movie on their love story.

Two youths, a Muslim and a Hindu, get trapped in a religious clash in North India. Can they escape from the situation?

Owing to the condition that the girls of the neighborhood should be treated like one's own sister, Gattu works to capture Binny's heart and the approval of his community.

Passed off as spies, two inept pals are sent to Fiji to rescue a kidnapped bureaucrat. Soon enough, they’re creating more problems than they’re solving.

A pair of reformed gangsters try to find a husband for their newly discovered sister, but complications arise due to mistaken identities.

A small time detective is hired to bring back the daughter of a businessman who has run away from home with the house chef.

Bank robbers, diamond thieves, a minister's homicide, and a hyper wife are just some of the challenges faced by a bumbling senior police officer.

A man falls in love with a beautiful woman, but later discovers that her brothers are gangsters.