Based on the Medical entrance exam scam, Vidya has been blackmailed and kidnapped by Dhansu Yadav who is running the scam. Her brother Aditya is on a hunt to get Vidya back but eventually gets trapped and got arrested under the scam.

Set in present-day Lucknow (India), Gulabo Sitabo is a social satire about two impossibly peculiar human beings, Mirza Chunnan Nawab, who stays in a dilapidated mansion and one of the tenants, Bankey Rastogi.

The friendship of two men is tested when things go wrong in their blood theft business.